# on 31-Jul-2016 (Sun)

#### Flashcard 149669271

Tags
#finance #inflation #inflation-derivatives #inflation-derivatives-barcap
Question
the payment of the cumulative percentage in the price index over the tenor of the zero coupon inflation swap formula is
$$\Large notional(\frac{InflationIndex_{i+tenor}}{InflationIndex_i}-1)$$

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the payment of the cumulative percrentage in the price index over the tenor of the zero coupon inflation swap formula is notional(InflationIndexi+tenorInflationIndexi−1)

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#### Annotation 149672454

 #finance #steiner-mastering-financial-calculations-3ed because a FRA is traded on an interest rate and a futures contract is traded on a price, FRAs and futures are in opposite directions

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#### Flashcard 150897391

Tags
#artificial-intelligence #minsky #society-of-mind
Question
I suspect that, in order to commit ourselves to our largest, most ambitious plans, we learn to exploit agencies that operate on larger spans of time. Which are our slowest-changing agencies of all? Later we'll see that these must include the silent, hidden agencies that shape what we call [...]. These are the systems that are concerned not merely with the things we want , but with what we want ourselves to be-that is, the ideals we set for ourselves
character

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our largest, most ambitious plans, we learn to exploit agencies that operate on larger spans oftime. Which are our slowest-changing agencies of all? Later we'll see that these must include the silent, hidden agencies that shape what we call <span>character. These are the systems that are concerned not merely with the things we want , but with what we want ourselves to be-that is, the ideals we set for ourselves <span><body></html

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#### Annotation 1376068963596

 #pharmacology #selectivity #specificity #su803 Selectivity depicts a molecule with greater affinity for one receptor (or any process for that matter) over another. The key is that implicit in this definition (or rather characterization), is that the selectivity can be "overcome" by overloading the system, and the "other" receptor experiences binding and/or activation. Specificity takes selectivity one step further, where no increase in the ligand or molecule of interest can activate the other receptor(s).

PharmPK Discussion List Archive - PK2008445.html - 2008
ed,Bioanalytical Division,Bangalore,Email: vijay_b.aaa.aurigene.com Back to the Top On 9 Dec 2008 at 13:00:25, "Shawn Spencer" (shawn.spencer.aaa.famu.edu) sent the message The following message was posted to: PharmPKSure Vijay,<span>Selectivity depicts a molecule with greater affinity for one receptor(orany process for that matter) over another. The key is that implicitin thisdefinition (or rather characterization), is that the selectivity can be"overcome" by overloading the system, and the "other" receptorexperiencesbinding and/or activation.Specificity takes selectivity one step further, where no increase in theligand or molecule of interest can activate the other receptor(s).Hope that helps.CheersSHAWN SPENCER, PhD.Assistant Professor of BiopharmaceuticsDyson Bldg., Rm 227College of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahassee, F

#### Annotation 1376072633612

 #pharmacology #selectivity #specificity #su803 Here are my two cents: The words selectivity, specificity, and sensitivity (derived from Latin seligere, specificus, sensitivus), can be confusing terms as they are often used synonymously in the medical literature. However, they should not be used interchangeably as each represents a different phenomenon: The word selectivity describes a drug's ability to affect a particular cell populationin preference to others. Selectivity is generally a worthy property in a drug because a drug having high selectivity may have a dramatic effect when there is a single agent that can be targeted against the appropriate molecular-driver involved in the pathogenesis of a disease. Selectivity is used to describe the ability of a drug to affect a particular population, i.e., gene, protein, signaling pathway, or cell, in preference to others. For example a selective drug would have the ability to discriminate between cell or receptor populations, and so affect only one cell population, and thereby produce an event. Specificity, a term most often confused with selectivity, is used to describe the capacity of a drug to cause a particular action in a population. For example, a drug of absolute specificity of action might decrease or increase, a specific function of a given gene or protein or cell type, but it must do either, not both. Sensitivity is used to describe the capacity of a population, to respond to a drug's ability, to stimulate that entity at a specified dose. The smaller the dose required producing an effect, the more sensitive is the responding system. (The word used to describe this activity in the drug which is the cause of the population sensitivity, is potency).

PharmPK Discussion List Archive - PK2008445.html - 2008
e of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahassee, FL 32307shawn.spencer.aaa.famu.edu Back to the Top On 9 Dec 2008 at 13:45:13, "Murad Melhem" (melhemmr.at.gmail.com) sent the message Hi Veeravalli,<span>Here are my two cents:The words selectivity, specificity, and sensitivity (derived fromLatin seligere, specificus, sensitivus), can be confusing terms asthey are often used synonymously in the medical literature. However,they should not be used interchangeably as each represents a differentphenomenon:The word selectivity describes a drug's ability to affect a particularcell populationin preference to others. Selectivity is generally aworthy property in a drug because a drug having high selectivity mayhave a dramatic effect when there is a single agent that can betargeted against the appropriate molecular-driver involved in thepathogenesis of a disease. Selectivity is used to describe theability of a drug to affect a particular population, i.e., gene,protein, signaling pathway, or cell, in preference to others. Forexample a selective drug would have the ability to discriminatebetween cell or receptor populations, and so affect only one cellpopulation, and thereby produce an event.Specificity, a term most often confused with selectivity, is used todescribe the capacity of a drug to cause a particular action in apopulation. For example, a drug of absolute specificity of actionmight decrease or increase, a specific function of a given gene orprotein or cell type, but it must do either, not both.Sensitivity is used to describe the capacity of a population, torespond to a drug's ability, to stimulate that entity at a specifieddose. The smaller the dose required producing an effect, the moresensitive is the responding system. (The word used to describe thisactivity in the drug which is the cause of the population sensitivity,is potency).I hope this helps.Murad Back to the Top On 9 Dec 2008 at 20:11:17, =?ISO-8859-1?Q?Andr=E9_Mateus?= (andrenmateus.-at-.gmail.com) sent the message The following message was posted to

#### Annotation 1376074206476

 #pharmacology #selectivity #specificity #su803 A method is specific if it produces a response for only one single analyte. Since it is almost impossible to develop a chromatographic assay for a drug in a biological matrix that will respond to only the compound of interest, the term selectivity is more appropriate. Selectivity of a method is its ability to produce a response for the target analyte which is distinguishable from all other responses (e.g. endogenous compounds).

PharmPK Discussion List Archive - PK2008445.html - 2008
NIPER,Sec-67, S.A.S. NagarMohali, Punjab-160062 Back to the Top On 11 Dec 2008 at 13:04:41, "Sivacharan Kollipara" (Sivacharan.Kollipara.-at-.ranbaxy.com) sent the message The following message was posted to: PharmPKDear Sachin,<span>A method is specific if it produces a response for only one singleanalyte. Since it is almost impossible to develop a chromatographicassay for a drug in a biological matrix that will respond to only thecompound of interest, the term selectivity is more appropriate.Selectivity of a method is its ability to produce a response for thetarget analyte which is distinguishable from all other responses (e.g.endogenous compounds).J. LIQ. CHROM. & REL TECHNOL., 23(3), 329-354 (2000).You can also find the cross references in the same article.Hope this helps.RegardsSivacharan KolliparaMetabolism & Pharmacoki

#### Annotation 1376078400780

Specificity vs. Selectivity, and the Therapeutic Window
#pharmacology #selectivity #specificity #su803

### If a drug has one effect, and only one effect on all biological systems it possesses the property of specificity. In experience, the vast majority of drugs are selective rather than specific. This is the case because most drugs will act on more than one receptor site once they reach an appropriately high concentration. Two examples include: a) verapamil, a blocker of L-type Ca channels, but which blocks Na channels at high concentrations; b) yohimbine a drug used therapeutically as an α2-adrenoceptor blocker but which also blocks 5-HT receptors, α1-adrenoceptors, Na channels, monoamine oxidase, and cholinesterase at higher concentrations. The concentration range over which a drug produces its therapeutic effect is known as its therapeutic window. An illustration of the therapeutic window for selective blockade of α2-adrenoceptors by yohimbine is shown in Figure 11.

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ses when stimulated. These receptor subtypes are not typically expressed in equal amounts in the same tissue (e.g. vascular smooth muscle contains more α receptors (α » β ), whereas bronchial tissue contains more β receptors (β » α). <span>Specificity vs. Selectivity, and the Therapeutic Window If a drug has one effect, and only one effect on all biological systems it possesses the property of specificity . In experience, the vast majority of drugs are selective rather than specific. This is the case because most drugs will act on more than one receptor site once they reach an appropriately high concentration. Two examples include: a) verapamil, a blocker of L-type Ca channels, but which blocks Na channels at high concentrations; b) yohimbine a drug used therapeutically as an α2-adrenoceptor blocker but which also blocks 5-HT receptors, α1-adrenoceptors, Na channels, monoamine oxidase, and cholinesterase at higher concentrations. The concentration range over which a drug produces its therapeutic effect is known as its therapeutic window . An illustration of the therapeutic window for selective blockade of α2-adrenoceptors by yohimbine is shown in Figure 11. Figure 11. The therapeutic window for selective blockade of α2 - adrenoceptors by yohimbine. Similar to most drugs, yohimbine lacks true specificity in its biological actions.

#### Annotation 1377342721292

 Unique pathophysiologic aspects of genetic diseases, 1 #2 #chp #module1 #pathophysiology #ppd7 #su810 Although the phenotypes of genetic diseases are diverse, their causes are not. Th e primary cause of any genetic disease is a change in the sequence or cellular content of DNA that ultimately deranges gene expression.

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#### Annotation 1377345080588

 #2 #chp #module1 #pathophysiology #ppd7 #su810 Most genetic diseases are caused by an alteration in DNA sequence that alters the synthesis of a single gene product.

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#### Annotation 1377347439884

 #chp2 #module1 #pathophysiology #ppd7 #su810 Some genetic diseases are caused by (1) structural rearrangements that result in deletion or duplication of a group of closely linked genes or (2) abnormalities during mitosis or meiosis that result in an abnormal number of chromosomes per cell.

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#### Flashcard 1377386499340

Tags
#finance #steiner-mastering-financial-calculations-3ed
Question
A FRA settlement is paid at the [...] of the notional borrowing period, and is discounted.
beginning

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A FRA settlement is paid at the beginning of the notional borrowing period, and is discounted.

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#### Flashcard 1377388072204

Tags
#finance #steiner-mastering-financial-calculations-3ed
Question
A FRA settlement is paid at the beginning of the [...], and is discounted.
notional borrowing period

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A FRA settlement is paid at the beginning of the notional borrowing period, and is discounted.

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#### Flashcard 1377389645068

Tags
#finance #steiner-mastering-financial-calculations-3ed
Question
A FRA settlement is paid at the beginning of the notional borrowing period, and is [...].
discounted

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A FRA settlement is paid at the beginning of the notional borrowing period, and is discounted.

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#### Annotation 1377505250572

 #artificial-intelligence #minsky #society-of-mind Furthermore, as we'll shortly see, the relations between mental agents are not always strictly hierarchical.

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