on 14-Aug-2019 (Wed)

The international TNM-based staging system describes the anatomical extent of the disease

The T category describes the size and extent of the primary tumor. The N category describes the extent of involvement of regional lymph nodes. The M category describes the presence or absence of distant metastatic spread. The addition of numbers to these categories describes the extent of the cancer.

TNM subsets with similar prognoses are then combined into stage groupings. NSCLC stages range from one to four (I through IV).

The lower the stage, the less the cancer has spread.

combinations of the T, N, and M categories are then used to create TNM subsets (Table 2). TNM subsets with similar prognoses are then combined into stage groupings. NSCLC stages range from one to four (I through IV). The lower the stage, the less the cancer has spread. SCLC is defined using two stages: Limited (confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes) and extensive (spread beyond the supraclavicular areas)

Близорукость, или миопия — это нарушение преломляющей системы глаза, сопровождающееся плохим зрением вдаль.

Со слезами из организма удаляются вредные вещества, образующиеся при нервном напряжении или стрессе.

Грецкие орехи. Содержат большое количество полиненасыщенных кислот, которые оказывают благотворное воздействие на работу глаз.

Морковь. Является источником провитамина А. Питает слезные железы.

Шоколад. Активизирует работу слезных протоков, в результате чего они получают защиту от застоя и возможного образования камней.

Цикорий. Усиливает кровообращение, а также ускоряет обменные процессы, происходящие в железах. Благодаря этому, слезные железы приобретают защиту от камнеобразования.

А мужчинам, чтобы заплакать, следует… резать лук!

предотвращение возникновения симптомов синдрома «сухого глаза» за счет стимуляции работы слезных желез;

Медикаменты. Многие медикаменты нарушают состояние печени. Печень соответственно влияет на зрение.

Медикаменты.

Печень соответственно влияет на зрение. Правда ли это?

Сухость глаз также может вызвать сильный ветер. Если такового нет, можно попросить кого-то интенсивно подуть вам в глаза.

При использовании компьютера, смартфона или другого цифрового устройства, мы, как правило реже моргаем. В результате может развиться сухость в глазах. Делайте сознательное усилие и моргайте чаще при использовании этих устройств.

four primary drivers of sustainability: (a) the organizational purposes for selection, (b) HR strategy, (c) governance, and (d) process man- agement.

Although the type of test chosen for a given purpose shapes the implementation, so too do implementation constraints imposed by the organization for which the test is developed or selected restrict the nature of the test that is chosen. Thus, implementation issues must be considered before a test format is chosen and research and development begin to ensure the test fits the organization’s needs and staffing context and reconsidered when the test is complete to ensure the implementation procedures support valid interpretations of test scores. Because many implementation decisions affect other decisions about implementation as well as the choice of test, an iterative process in which decisions are revisited will result in an implementation plan that is aligned with the nature of the test to be given and the conditions under which it is to be given. For example, a decision to create only one form of a test to control development costs may limit the frequency with which retests are offered. Conversely, a requirement to allow retests every 6 months based on union contracts, corporate culture, or past practices may necessitate the development of multiple forms or the selection of test types that are less susceptible to practice effects.

most patients eventually relapse, and treatment at this stage may be particularly complex.

At the time of relapse, the use of alternative drugs to those given upfront is current practice.

recently approved drugs, such as the second- and third-generation proteasome inhibitors carfilzomib and ixazomib, the immunomodulatory agent pomalidomide, the monoclonal antibodies daratumumab and elotuzumab and the histone deacetylase inhibitor panobinostat, but also new targeted agents are under active investigation (e.g. signal trans- duction modulators, kinesin spindle protein inhibitors, and inhibitors of NF-kB, MAPK, AKT)

We discuss problems the null hypothesis significance testing (NHST) paradigm poses for replication and more broadly in the biomedical and social sciences as well as how these problems remain unresolved by proposals involving modified p-value thresholds, confidence intervals, and Bayes factors

Specifically, we propose that the p-value be demoted from its threshold screening role and instead, treated continuously, be considered along with currently subordinate factors (e.g., related prior evidence, p lausibility of mechanism, study design and data quality, real world costs and benefits, novelty of finding, and other factors that vary by research domain) as just one among many pieces of evidence.

related prior evidence, plausibility of mechanism, study design and data quality, real world costs and benefits, novelty of finding, and other factors that v ary by research domain (for want of a b etter term, we hereafter refer to these collectively as the currently subordinate factors)