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Annotation 7671943662860

#MMR #Maladies-infectieuses-et-tropicales #Measles #MedicalMicrobiology2013-MMR #MedicalMicrobiology2013-Paramyxorividae #MedicalMicrobiology2013-Paramyxovirus #MedicalMicrobiology2013-ROR #Mumps #Oreillons #Paramyxorividae #Paramyxovirus #ROR #Rougeole #Rubella #Rubeole #Virologie #Virology

Paramyxoviruses are relatively large viruses with a negative- sense, single-stranded ribonucleic acid (RNA) (5 to 8 × 106 Da) genome in a helical nucleocapsid surrounded by a pleo- morphic envelope of approximately 156 to 300 nm (Figure 48-1)

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Annotation 7671945235724

Although there are simi- larities in paramyxovirus genomes, the order of the protein- coding regions differs for each genus

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Annotation 7671946808588

The nucleocapsid consists of the negative-sense, single- stranded RNA associated with the nucleoprotein (N), poly- merase phosphoprotein (P), and large (L) protein. The L protein is the RNA polymerase, the P protein facilitates RNA synthesis, and the N protein helps maintain genomic struc- ture.

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Annotation 7671948381452

The nucleocapsid associates with the matrix (M) protein lining the inside of the virion envelope

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Annotation 7671949954316

The envelope con- tains two glycoproteins, a fusion (F) protein, and a viral attachment protein (hemagglutinin-neuraminidase [HN], hemagglutinin [H], or glycoprotein [G] protein)

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Annotation 7671951527180

To express membrane-fusing activity, the F protein must be activated by proteolytic cleavage, which produces F1 and F2 glycopeptides held together by a disulfide bond.

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Annotation 7671953100044

Addi- tional proteins (V, C, and W) result from alternative tran- scripts of the P gene and facilitate escape from innate host protections

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Annotation 7671956245772

[unknown IMAGE 7671954935052]

Paramyxovirus

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Annotation 7671958080780

Replication of the paramyxoviruses is initiated by the binding of the HN, H, or G glycoprotein on the virion enve- lope to their receptors. The HN of parainfluenza viruses bind to sialic acid on cell surface glycolipids and glycoproteins. Like influenza, they use the neuraminidase activity to cleave sialic acid on viral and cellular glycoproteins, prevent binding to itself, and facilitate exit from the cell. The other paramyxo- viruses bind to protein receptors and do not need a neur- aminidase activity.

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Annotation 7671959653644

Paramyxoviruses are also able to induce cell-to-cell fusion, thereby creating mul- tinucleated giant cells (syncytia)

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Annotation 7671961226508

The RNA polymerase is carried into the cell as part of the nucleocapsid. Transcription, protein synthesis, and replication of the genome all occur in the host cell’s cyto- plasm. The genome is transcribed into individual messenger RNAs (mRNAs) and a full-length positive-sense RNA tem- plate.

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Annotation 7671962799372

New genomes associate with the L, N, and N proteins to form helical nucleocapsids that associate with the M pro- teins on viral glycoprotein-modified plasma membranes. The glycoproteins are synthesized and processed like cellular glycoproteins.

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Annotation 7671964372236

Mature virions then bud from the host cell plasma membrane and exit without killing the cell. Replica- tion of the paramyxoviruses is represented by the RSV infec- tious cycle shown in Figure 48-2

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Annotation 7671966469388

The three genera can be distinguished by the activities of the viral attach- ment protein: HN of parainfluenza virus and mumps virus binds to sialic acid and red blood cells (hemagglutinin) and neuraminidase activity, H of measles virus binds protein receptors and is also a hemagglutinin, but G of RSV binds to cells but is not a hemagglutinin

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Annotation 7671968042252

Cell-mediated immunity causes many of the symptoms but is essential for control of the infection.

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Annotation 7671969615116

Paramyxoviridae are transmitted in respiratory droplets and initiate infection in the respiratory tract

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Annotation 7671973022988

[unknown IMAGE 7671971712268]

Proteines paramyxovirus

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Annotation 7671975120140

[unknown IMAGE 7671973809420]

Caracteristiques paramyxovirus

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Annotation 7671977217292

[unknown IMAGE 7671975906572]

Replication paramyxovirus

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Flashcard 7672089939212

Tags

#Maladies-infectieuses-et-tropicales #Mumps #Mumps-MDB #Oreillons #Oreillons-MDB #Virologie #Virology

Question

Quelle est l'atteinte clinique principale des oreillons ?

Answer

Inflammation des glandes salivaires

"Mumps is an acute viral infection that most commonly manifests as nonsuppurative swelling and tenderness of the parotid or other salivary glands caused by the mumps virus"

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Definition Mumps is an acute viral infection that most commonly manifests as nonsuppurative swelling and tenderness of the parotid or other salivary glands caused by the mumps virus. Less common manifestations of mumps include meningitis, encephalitis, epididymo-orchitis, oophoritis, and pancreatitis

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Flashcard 7672092298508

Tags

#Maladies-infectieuses-et-tropicales #Mumps #Mumps-MDB #Oreillons #Oreillons-MDB #Virologie #Virology

Question

Quels sont les organes ou systèmes d'organes pouvant être atteints au cours d'une infection par le virus des oreillons

Answer

Neurologique

Reproductif

Pancréatique

"Less common manifestations of mumps include meningitis, encephalitis, epididymo-orchitis, oophoritis, and pancreatitis"

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pan> Definition Mumps is an acute viral infection that most commonly manifests as nonsuppurative swelling and tenderness of the parotid or other salivary glands caused by the mumps virus. Less common manifestations of mumps include meningitis, encephalitis, epididymo-orchitis, oophoritis, and pancreatitis <span>

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Flashcard 7672094919948

Tags

#Maladies-infectieuses-et-tropicales #Mumps #Mumps-MDB #Oreillons #Oreillons-MDB #Virologie #Virology

Question

Quel(s) est (sont) le(s) hôte(s) naturel(s) du virus des oreillons ?

Answer

Humains

"Mumps is endemic throughout the world, and humans are the only natural hosts for the virus"

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Epidemiology Mumps is endemic throughout the world, and humans are the only natural hosts for the virus. Incubation period is usually 16 to 18 days, with a range of 2 to 4 weeks. Before the introduction of the mumps vaccine in the United States in 1967, epidemics occurred every 2 to 5 yea

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Flashcard 7672097279244

Tags

#Maladies-infectieuses-et-tropicales #Mumps #Mumps-MDB #Oreillons #Oreillons-MDB #Virologie #Virology

Question

Quelle est la période d'incubation des oreillons ?

Answer

16 à 18 jours
donc entre 2 et 4 semaines

"Incubation period is usually 16 to 18 days, with a range of 2 to 4 weeks"

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Parent (intermediate) annotation

Original toplevel document (pdf)

Parent (intermediate) annotation

Original toplevel document (pdf)

Parent (intermediate) annotation

Original toplevel document (pdf)

Parent (intermediate) annotation

Original toplevel document (pdf)