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Annotation 7682166230284

#M2_Buruli_Physiopathologie_Pluschke
After the first definite description in 1948, M. ulcerans infections have been reported from 34 countries, mainly with tropical and subtropical climates.
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Buruli Ulcer: History and Disease Burden - Buruli Ulcer - NCBI Bookshelf
l: hc.hptssiws@ekhcsulp.dreg Corresponding author. Published online: April 30, 2019. Buruli ulcer (BU) is a neglected, debilitating skin disease caused by infection with Mycobacterium ulcerans. <span>After the first definite description in 1948, M. ulcerans infections have been reported from 34 countries, mainly with tropical and subtropical climates. Following a peak of 5954 reported BU cases globally in 2004 the number of new recorded cases has been decreasing over the past years. In 2016, a total of 1952 BU cases were reported to



Annotation 7682167803148

#M2_Buruli_Physiopathologie_Pluschke
Following a peak of 5954 reported BU cases globally in 2004 the number of new recorded cases has been decreasing over the past years. In 2016, a total of 1952 BU cases were reported to the World Health Organization (WHO) from twelve different countries.
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Buruli Ulcer: History and Disease Burden - Buruli Ulcer - NCBI Bookshelf
infection with Mycobacterium ulcerans. After the first definite description in 1948, M. ulcerans infections have been reported from 34 countries, mainly with tropical and subtropical climates. <span>Following a peak of 5954 reported BU cases globally in 2004 the number of new recorded cases has been decreasing over the past years. In 2016, a total of 1952 BU cases were reported to the World Health Organization (WHO) from twelve different countries. Underreporting is considered likely, as BU mostly affects populations in remote areas with limited access to the formal health sector. Although transmission pathways of M. ulcerans are



Annotation 7682169376012

#M2_Buruli_Physiopathologie_Pluschke
The key event for the emergence of M. ulcerans as a species highly pathogenic for humans appears to be the acquisition of a plasmid, bearing genes encoding polyketide synthases and polyketide-modifying enzymes involved in the biosynthesis of a unique macrolide toxin, named mycolactone.
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Buruli Ulcer: History and Disease Burden - Buruli Ulcer - NCBI Bookshelf
r, infection foci are closely associated with wetlands. Considering that M. ulcerans has evolved from the fish pathogen M. marinum, involvement of an environmental niche is strongly suggestive. <span>The key event for the emergence of M. ulcerans as a species highly pathogenic for humans appears to be the acquisition of a plasmid, bearing genes encoding polyketide synthases and polyketide-modifying enzymes involved in the biosynthesis of a unique macrolide toxin, named mycolactone. The cytotoxic and immunosuppressive properties of mycolactone account for much of the pathology of BU, which is characterized by the formation of chronic, necrotizing, ulcerative skin l



Annotation 7682476608780

ribing memory traces in learning (the other is stability). Retrievability is most often expressed as the
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Glossary:Retrievability - SuperMemo Help
Glossary:Retrievability - SuperMemo Help Glossary:Retrievability From SuperMemo Help Jump to navigation Jump to search retrievability one of the two variables describing memory traces in learning (the other is stability). Retrievability is most often expressed as the probability of recall. Retrievability is subject to negatively exponential decline whose speed depends on memory stability. Stability is often expressed as the optimum interval for the