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Open it >Constitutively active receptors can exist and are shifted toward the activated state, even though no agonist or ligand is present. Receptors for benzodiazepines, cannabinoids, and serotonin are examples. Agonists shift the equilibrium toward <span>activation. Antagonists freeze the equilibrium, and inverse ago- nists shift the equilibrium toward inactivation. The two-state model<span><body><html>
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