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Glycolysis (a sweet splitting process) is a central pathway for the catabolism of carbohydrates in which the six-carbon sugars are split to three-carbon compounds with subsequent release of energy used to transform ADP to ATP. Glycolysis can proceed under anaerobic (without oxygen) and aerobic conditions.

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Glycolysis
phosphate isomerase6. Glyceraldehyde-3-phosphate dehydrogenase7. Phosphoglycerate kinase8. Phosphoglycerate mutase9. Enolase10. Pyruvate kinaseCompounds:ATPADPGlucosePyruvate Glycolysispublished: 21 Nov 2011 (3:12) Glycolysis, an overview<span>Glycolysis (a sweet splitting process) is a central pathway for the catabolism of carbohydrates in which the six-carbon sugars are split to three-carbon compounds with subsequent release of energy used to transform ADP to ATP. Glycolysis can proceed under anaerobic (without oxygen) and aerobic conditions.Why the glycolysis, is the most interesting pathway for studies? First of all, this pathway is almost universal across all living organisms, and therefore all proteins or enzymes which a




Flashcard 149622607

Question
Glycolysis is a 10-step pathway which converts glucose to
Answer
2 pyruvate molecules


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Glycolysis
re involved in catalysis are very similar across all organisms. Secondly, glycolysis is one of the ancient metabolic pathways in living cells. Finally, glycolysis is the first pathway which was studied in detail.Glycolysis, an overall equation<span>Glycolysis is a 10-step pathway which converts glucose to 2 pyruvate molecules. The overall Glycolysis step can be written as a net equation:Glucose + 2xADP + 2xNAD+ -> 2xPyruvate + 2xATP + 2xNADHGlycolysis consists from two main phases. First phase, energy i







Glycolysis consists from two main phases. First phase, energy investment. During this step 2xATP are converted to 2xADP molecules. Second phase, energy generation. During this step 4xADP are converted to 2xATP molecules and 2xNAD+ are converted to 2xNADH molecules.

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Glycolysis
in detail.Glycolysis, an overall equationGlycolysis is a 10-step pathway which converts glucose to 2 pyruvate molecules. The overall Glycolysis step can be written as a net equation:Glucose + 2xADP + 2xNAD+ -> 2xPyruvate + 2xATP + 2xNADH<span>Glycolysis consists from two main phases. First phase, energy investment. During this step 2xATP are converted to 2xADP molecules. Second phase, energy generation. During this step 4xADP are converted to 2xATP molecules and 2xNAD+ are converted to 2xNADH molecules.Diagram of Glycolysis pathwayGlycolysis: Energy investment phaseGlycolysis step 1: Glucose phosphorylation catalysed by Hexokinase:α-D-Glucose + ATP -> α-D-Glucose-6-phosphate + ADP +




Flashcard 149622621

Question
Glucose phosphorylation is catalyzed by
Answer
Hexokinase


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Glycolysis
rted to 2xADP molecules. Second phase, energy generation. During this step 4xADP are converted to 2xATP molecules and 2xNAD+ are converted to 2xNADH molecules.Diagram of Glycolysis pathwayGlycolysis: Energy investment phaseGlycolysis step 1: <span>Glucose phosphorylation catalysed by Hexokinase:α-D-Glucose + ATP -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Gluc







Flashcard 149622630

Question
Answer
α-D-Glucose-6-phosphate + ADP + H+


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Glycolysis
neration. During this step 4xADP are converted to 2xATP molecules and 2xNAD+ are converted to 2xNADH molecules.Diagram of Glycolysis pathwayGlycolysis: Energy investment phaseGlycolysis step 1: Glucose phosphorylation catalysed by Hexokinase:<span>α-D-Glucose + ATP -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlyc







Flashcard 149622640

Question
The Isomerization of glucose-6-phosphate catalysed by


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Glycolysis
2xNADH molecules.Diagram of Glycolysis pathwayGlycolysis: Energy investment phaseGlycolysis step 1: Glucose phosphorylation catalysed by Hexokinase:α-D-Glucose + ATP -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: <span>Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-F







Flashcard 149622649

Question
α-D-Glucose-6-phosphate (Isomerization of G6P) <=>
Answer
D-Fructose-6-phosphate


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Glycolysis
ent phaseGlycolysis step 1: Glucose phosphorylation catalysed by Hexokinase:α-D-Glucose + ATP -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:<span>α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGly







Second phosphorylation catalysed by Phosphofructokinase:

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Glycolysis
P -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: <span>Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:Cleavage to two Triose phosphates catalysed by Aldolase: D-Fructose-1,6-bisph




Flashcard 149622663

Question
F6P is catalysed by_ and becomes_
Answer
Phosphofructokinase. 1,6 Bisphosphate


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Glycolysis
P -> α-D-Glucose-6-phosphate + ADP + H+δGo = -16.7 kJ/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: <span>Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:Cleavage to two Triose phosphates catalysed by Aldolase: D-Fructose-1,6-bisph







D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+

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Glycolysis
/molGlycolysis step 2: Isomerization of glucose-6-phosphate catalysed by Phosphoglucoisomerase:α-D-Glucose-6-phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: Second phosphorylation catalysed by Phosphofructokinase:<span>D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:Cleavage to two Triose phosphates catalysed by Aldolase: D-Fructose-1,6-bisphosphate <=> Dihydroxyacetone phosphate + D-glyceroaldehyde-3-phosph




Flashcard 149622677

Question
Cleavage of 1,6 BP to two Triose phosphates catalysed by:
Answer


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Glycolysis
phosphate <=> D-Fructose-6-phosphateδGo = +1.7 kJ/molGlycolysis step 3: Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:<span>Cleavage to two Triose phosphates catalysed by Aldolase: D-Fructose-1,6-bisphosphate <=> Dihydroxyacetone phosphate + D-glyceroaldehyde-3-phosphateδGo = +28 kJ/molGlycolysis step 5:Isomerization of dihydroxyacetone phosphate catalysed by







Flashcard 149622686

Question
D-Fructose-1,6-bisphosphate With Aldolase in an ATP sufficient cell becomes:
D-Fructose-1,6-bisphosphate With Aldolase in an ATP defecient cell beomce:
Answer
Dihydroxyacetone phosphate (DHAP)
+ D-glyceroaldehyde-3-phosphate (G3P)


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Glycolysis
olGlycolysis step 3: Second phosphorylation catalysed by Phosphofructokinase:D-Fructose-6-phosphate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:Cleavage to two Triose phosphates catalysed by Aldolase: <span>D-Fructose-1,6-bisphosphate <=> Dihydroxyacetone phosphate + D-glyceroaldehyde-3-phosphateδGo = +28 kJ/molGlycolysis step 5:Isomerization of dihydroxyacetone phosphate catalysed by Triose phosphate isomerase:Dihydroxyacetone phosphate <=> D-glyceroaldehyde-3-phosphateδG







Flashcard 149622695

Question
To interconvert between DHAP and G3P, You will need the enzyme:
Answer
Triphosphate Isomerase


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Glycolysis
ate + ATP -> D-Fructose-1,6-bisphosphate + ADP + H+δGo = -18.5 kJ/molGlycolysis step 4:Cleavage to two Triose phosphates catalysed by Aldolase: D-Fructose-1,6-bisphosphate <=> Dihydroxyacetone phosphate + D-glyceroaldehyde-3-phosphate<span>δGo = +28 kJ/molGlycolysis step 5:Isomerization of dihydroxyacetone phosphate catalysed by Triose phosphate isomerase:Dihydroxyacetone phosphate <=> D-glyceroaldehyde-3-phosphateδGo = +7.6 kJ/molG







Dihydroxyacetone phosphate <=> D-glyceroaldehyde-3-phosphate

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Glycolysis
hates catalysed by Aldolase: D-Fructose-1,6-bisphosphate <=> Dihydroxyacetone phosphate + D-glyceroaldehyde-3-phosphateδGo = +28 kJ/molGlycolysis step 5:Isomerization of dihydroxyacetone phosphate catalysed by Triose phosphate isomerase:<span>Dihydroxyacetone phosphate <=> D-glyceroaldehyde-3-phosphateδGo = +7.6 kJ/molGlycolysis: Energy generation phase3-BisphosphoglycerateGlycolysis step 6:Generation of 1,3-Bisphosphoglycerate catalysed by Glyceraldehyde-3-phosphate dehydrogenase:D-g




Flashcard 149622709

Question
G3P to 1,3-Bisphosphoglycerate is catalyzed by:


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Glycolysis
5:Isomerization of dihydroxyacetone phosphate catalysed by Triose phosphate isomerase:Dihydroxyacetone phosphate <=> D-glyceroaldehyde-3-phosphateδGo = +7.6 kJ/molGlycolysis: Energy generation phase3-BisphosphoglycerateGlycolysis step 6:<span>Generation of 1,3-Bisphosphoglycerate catalysed by Glyceraldehyde-3-phosphate dehydrogenase:D-glyceroaldehyde-3-phosphate + NAD+ +Pi <=> 1,3-Bisphosphoglycerate + NADH + H+δGo = +6.3 kJ/mol 3-PhosphoglycerateGlycolysis step 7:Substrate-level phosphorylation, 3-Phosphoglyc







D-glyceroaldehyde-3-phosphate + NAD+ +Pi <=> 1,3-Bisphosphoglycerate + NADH + H+

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Glycolysis
oxyacetone phosphate <=> D-glyceroaldehyde-3-phosphateδGo = +7.6 kJ/molGlycolysis: Energy generation phase3-BisphosphoglycerateGlycolysis step 6:Generation of 1,3-Bisphosphoglycerate catalysed by Glyceraldehyde-3-phosphate dehydrogenase:<span>D-glyceroaldehyde-3-phosphate + NAD+ +Pi <=> 1,3-Bisphosphoglycerate + NADH + H+δGo = +6.3 kJ/mol 3-PhosphoglycerateGlycolysis step 7:Substrate-level phosphorylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:1,3-Bisphosphoglycerate + ADP <=> 3-P




Substrate-level phosphorylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:

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Glycolysis
sis step 6:Generation of 1,3-Bisphosphoglycerate catalysed by Glyceraldehyde-3-phosphate dehydrogenase:D-glyceroaldehyde-3-phosphate + NAD+ +Pi <=> 1,3-Bisphosphoglycerate + NADH + H+δGo = +6.3 kJ/mol 3-PhosphoglycerateGlycolysis step 7:<span>Substrate-level phosphorylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:1,3-Bisphosphoglycerate + ADP <=> 3-Phosphoglycerate + ATPδGo = -18.8 kJ/molGlycolysis step 8:Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:3-Phosph




Flashcard 149622728

Question
1,3-Bisphosphoglycerate + ADP:

1,3-BPG is catalyzed by:
Answer
3-Phosphoglycerate + ATP

Phosphoglycerate Kinase


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Glycolysis
dehydrogenase:D-glyceroaldehyde-3-phosphate + NAD+ +Pi <=> 1,3-Bisphosphoglycerate + NADH + H+δGo = +6.3 kJ/mol 3-PhosphoglycerateGlycolysis step 7:Substrate-level phosphorylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:<span>1,3-Bisphosphoglycerate + ADP <=> 3-Phosphoglycerate + ATPδGo = -18.8 kJ/molGlycolysis step 8:Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:3-Phosphoglycerate <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolys







Flashcard 149622737

Question
Phosphate transfer of 3-phosphoglycerate to 2-Phosphoglycerate is catalyzed by:


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Glycolysis
δGo = +6.3 kJ/mol 3-PhosphoglycerateGlycolysis step 7:Substrate-level phosphorylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:1,3-Bisphosphoglycerate + ADP <=> 3-Phosphoglycerate + ATPδGo = -18.8 kJ/molGlycolysis step 8:<span>Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:3-Phosphoglycerate <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolysis step 9:Synthesis of Phosphoenolpyruvate catalysed by Enolase:2-Phosphoglycerate <=> Phosphoenolpyruvate +







3-Phosphoglycerate <=> 2-Phosphoglycerate

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Glycolysis
ylation, 3-Phosphoglycerate catalysed by Phosphoglycerate kinase:1,3-Bisphosphoglycerate + ADP <=> 3-Phosphoglycerate + ATPδGo = -18.8 kJ/molGlycolysis step 8:Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:<span>3-Phosphoglycerate <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolysis step 9:Synthesis of Phosphoenolpyruvate catalysed by Enolase:2-Phosphoglycerate <=> Phosphoenolpyruvate + H2OδGo = +1.7 kJ/molGlycolysis step 10:Substra




2-Phosphoglycerate <=> Phosphoenolpyruvate + H2O

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Glycolysis
18.8 kJ/molGlycolysis step 8:Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:3-Phosphoglycerate <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolysis step 9:Synthesis of Phosphoenolpyruvate catalysed by Enolase:<span>2-Phosphoglycerate <=> Phosphoenolpyruvate + H2OδGo = +1.7 kJ/molGlycolysis step 10:Substrate-level phosphorylation. Pyruvate synthesis catalysed by Pyruvate kinase:Phosphoenolpyruvate + H+ + ADP -> Pyruvate + ATPδGo = -31.4 kJ/mol




Flashcard 149622756

Question
Synthesis of Phosphoenolpyruvate catalysed by
Answer
Enolase.

2PG ->(Enolase) creates H20 + Phosphoenol pyruvate


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Glycolysis
cerate + ADP <=> 3-Phosphoglycerate + ATPδGo = -18.8 kJ/molGlycolysis step 8:Phosphate transfer to 2-Phosphoglycerate catalysed by Phosphoglycerate mutase:3-Phosphoglycerate <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolysis step 9:<span>Synthesis of Phosphoenolpyruvate catalysed by Enolase:2-Phosphoglycerate <=> Phosphoenolpyruvate + H2OδGo = +1.7 kJ/molGlycolysis step 10:Substrate-level phosphorylation. Pyruvate synthesis catalysed by Pyruvate kinase:Phospho







Pyruvate synthesis catalysed by Pyruvate kinase:

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Glycolysis
te <=> 2-PhosphoglycerateδGo = +4.4 kJ/molGlycolysis step 9:Synthesis of Phosphoenolpyruvate catalysed by Enolase:2-Phosphoglycerate <=> Phosphoenolpyruvate + H2OδGo = +1.7 kJ/molGlycolysis step 10:Substrate-level phosphorylation. <span>Pyruvate synthesis catalysed by Pyruvate kinase:Phosphoenolpyruvate + H+ + ADP -> Pyruvate + ATPδGo = -31.4 kJ/molAnaerobic and Aerobic GlycolysisGlycolysis is an ancient metabolic pathway which was probably developed about 3.5 bil




Flashcard 149622770

Question
Phosphoenolpyruvate + H+ + ADP ->
Answer
Pyruvate + ATP


P
hopsphoenolpyruvate + H+ + ATP -> (Pruvate Kinase) === Pyruvate + ATP.

Either to TCA/ Kreb's Cycle or go towards anaerobic respiration AKA Lactic Acid cycle.


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Glycolysis
Glycolysis step 9:Synthesis of Phosphoenolpyruvate catalysed by Enolase:2-Phosphoglycerate <=> Phosphoenolpyruvate + H2OδGo = +1.7 kJ/molGlycolysis step 10:Substrate-level phosphorylation. Pyruvate synthesis catalysed by Pyruvate kinase:<span>Phosphoenolpyruvate + H+ + ADP -> Pyruvate + ATPδGo = -31.4 kJ/molAnaerobic and Aerobic GlycolysisGlycolysis is an ancient metabolic pathway which was probably developed about 3.5 billion years ago when there is no oxygen was availabl







Red blood cells take most of the energy from anaerobic metabolism

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Glycolysis
wayFor anaerobic Glycolysis pathway there are two major fermentation processes exists. Lactic acid fermentation. This pathway is common for animal cells and lactic acid bacteria. In animals the anaerobic glycolysis take place in many tissues. <span>Red blood cells take most of the energy from anaerobic metabolism. Skeletal muscle take energy from glycolysis and from respiration. The lactate produced utilise through diffusion from the tissues to bloodstream and then to aerobic tissues, such as li




The lactate produced utilise through diffusion from the tissues to bloodstream and then to aerobic tissues, such as liver and heart. In these aerobic tissues lactate can be catabolized further or can be converted back through gluconeogenesis.

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Glycolysis
on for animal cells and lactic acid bacteria. In animals the anaerobic glycolysis take place in many tissues. Red blood cells take most of the energy from anaerobic metabolism. Skeletal muscle take energy from glycolysis and from respiration. <span>The lactate produced utilise through diffusion from the tissues to bloodstream and then to aerobic tissues, such as liver and heart. In these aerobic tissues lactate can be catabolized further or can be converted back through gluconeogenesis.One step conversion of Pyruvate to Lactate catalysed by Lactate dehydrogenase.δGo = -25.1 kJ/molAlcoholic fermentation. This two-step pathway is common for yeast.Pyruvate -> Acetaldeh




Flashcard 149622789

Question
One step conversion of Pyruvate to Lactate catalyzed by:
Answer
Lactate dehydrogenase (LDH).


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Glycolysis
The lactate produced utilise through diffusion from the tissues to bloodstream and then to aerobic tissues, such as liver and heart. In these aerobic tissues lactate can be catabolized further or can be converted back through gluconeogenesis.<span>One step conversion of Pyruvate to Lactate catalysed by Lactate dehydrogenase.δGo = -25.1 kJ/molAlcoholic fermentation. This two-step pathway is common for yeast.Pyruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine







NAD+ -> NADH is considered an act of reduction (Add H+ or Remove Oxygen)

Oxidation is to add oxygen or remove hydrogen

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Glycolysis
m and then to aerobic tissues, such as liver and heart. In these aerobic tissues lactate can be catabolized further or can be converted back through gluconeogenesis.One step conversion of Pyruvate to Lactate catalysed by Lactate dehydrogenase.<span>δGo = -25.1 kJ/molAlcoholic fermentation. This two-step pathway is common for yeast.Pyruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine pyrophosphate, de




Pyruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine pyrophosphate, derived from vitamin B1 as a coenzyme

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Glycolysis
tate can be catabolized further or can be converted back through gluconeogenesis.One step conversion of Pyruvate to Lactate catalysed by Lactate dehydrogenase.δGo = -25.1 kJ/molAlcoholic fermentation. This two-step pathway is common for yeast.<span>Pyruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine pyrophosphate, derived from vitamin B1 as a coenzyme.Conversion of Acetaldehyde to Ethanol by Alcohol dehydrogenase.Aerobic Glycolysis pathwayWith the present of oxygen in cells pyruvate is oxidized to acetyl-CoA, which then enters the ci




Conversion of Acetaldehyde to Ethanol by Alcohol dehydrogenase

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Glycolysis
se.δGo = -25.1 kJ/molAlcoholic fermentation. This two-step pathway is common for yeast.Pyruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine pyrophosphate, derived from vitamin B1 as a coenzyme.<span>Conversion of Acetaldehyde to Ethanol by Alcohol dehydrogenase.Aerobic Glycolysis pathwayWith the present of oxygen in cells pyruvate is oxidized to acetyl-CoA, which then enters the citric acid cycle. The NADH molecules are reoxidized through the




With the present of oxygen in cells pyruvate is oxidized to acetyl-CoA, which then enters the citric acid cycle. The NADH molecules are reoxidized through the with electrons transferred to the O2 molecules.

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Glycolysis
ruvate -> Acetaldehyde + CO2 catalysed by Pyruvate decarboxylase. This reaction requires thiamine pyrophosphate, derived from vitamin B1 as a coenzyme.Conversion of Acetaldehyde to Ethanol by Alcohol dehydrogenase.Aerobic Glycolysis pathway<span>With the present of oxygen in cells pyruvate is oxidized to acetyl-CoA, which then enters the citric acid cycle. The NADH molecules are reoxidized through the with electrons transferred to the O2 molecules. The aerobic Glycolysis consists from two major steps:Glucose + 2xADP + 2xPi + 2xNAD+ =>2xPyruvate + 2xATP + 2xNADH + 2H+ + 2xH2ONADH oxidation pathway which generaly take place in the




Glucose + 2xADP + 2xPi + 2xNAD+ =>
2xPyruvate + 2xATP + 2xNADH + 2H+ + 2xH2O

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Glycolysis
oxygen in cells pyruvate is oxidized to acetyl-CoA, which then enters the citric acid cycle. The NADH molecules are reoxidized through the with electrons transferred to the O2 molecules. The aerobic Glycolysis consists from two major steps:<span>Glucose + 2xADP + 2xPi + 2xNAD+ =>2xPyruvate + 2xATP + 2xNADH + 2H+ + 2xH2ONADH oxidation pathway which generaly take place in the mitochohdrion:2xNADH + 8xH+ + O2 + 6xADP + 6xPi =>2xNAD+ + 8H2O + 6xATPThe final net equation for aerobic Glycolysis:Glucose +