# on 24-May-2022 (Tue)

#### Annotation 7071591959820

 #causality #statistics Definition 3.3 (blocked path) A path between nodes π and π is blocked by a (potentially empty) conditioning set π if either of the following is true: 1. Along the path, there is a chain Β· Β· Β· β π β Β· Β· Β· or a fork Β· Β· Β· β π β Β· Β· Β·, where π is conditioned on (π β π). 2. There is a collider π on the path that is not conditioned on ( π β π ) and none of its descendants are conditioned on (de(π) * π)

#### pdf

cannot see any pdfs

#### Flashcard 7088881143052

Tags
#causality #has-images #statistics

Question
We will take this table as the whole population of interest. Because of the fundamental problem of causal inference, this is fundamentally a missing data problem. All of the question marks in the table indicate that we do not [...] that cell.
observe

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
hole population of interest. Because of the fundamental problem of causal inference, this is fundamentally a missing data problem. All of the question marks in the table indicate that we do not <span>observe that cell. <span>

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088883240204

Tags
Question

The simple solution of [...] the customer table with the order table, consolidating all the information and then synthesising this big table will not work.

For two reasons:

1. Each synthesised row will be a new customer and order. But in reality we have to fix the customer and only then generate details at the order level β in other words, fix the parent and generate the child. This would leave us unable to constrain the number of products in any order, which is a key feature of the data that needs to be preserved.

2. The assumption of independence of rows is no longer valid for the customer table β each customer is independent of each other. However, the order details β products bought β are not independent. Some of these fields may even have dependencies on time and should be treated as a sequence: A given Product X is dependent on the presence of other products in the basket.

To address this particular case, let's consider two levels:

1. Customer level (name, address, etc) - that we call the βparent levelβ

2. Order details level (products, suppliers, etc) - that we call the βchild levelβ It is important to preserve this structure in the synthetic version because otherwise there could be misalignments and information leaks such as orders without customers or customers having unrealistic orders. This can be seen as a particular case of sequential data.

Some other examples where sequential data is common include:

electronic health records (EHR) data - diagnostics, exams

messages sent and received between two or many agents

measurements of physical systems taken over time

credit card transactions

Note that the finest grain may not be a sequence but the key insight is that data has a structure that has to be preserved β rows are not independent

left-joining

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
The simple solution of left-joining the customer table with the order table, consolidating all the information and then synthesising this big table will not work. For two reasons: 1. Each synthesised row will be a new cus

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088885075212

Tags
#causality #has-images #statistics

Question
in Figure 2.3. Because π is a [...] of π and π , there is non-causal association between π and π
common cause

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
in Figure 2.3. Because π is a common cause of π and π , there is non-causal association between π and π

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088887172364

Tags
#causality #statistics
Question
If [...] the paths between two nodes π and π are blocked, then we say that π and π are d-separated.
all

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
If all the paths between two nodes π and π are blocked, then we say that π and π are d-separated.

#### Original toplevel document (pdf)

cannot see any pdfs

#### Annotation 7088889007372

 #causality #statistics πΌ[π | do(π‘), π = π§] vs πΌ[π | π = π§] πΌ[π | π = π§] simply refers to the expected value in the (pre-intervention) population where individuals take whatever treatment they would normally take ( π ). This distinction will become important when we get to counterfactuals...

#### Parent (intermediate) annotation

Open it
he intervention do(π‘) occurs. For example, πΌ[π | do(π‘), π = π§] refers to the expected outcome in the subpopulation where π = π§ after the whole subpopulation has taken treatment π‘ . In contrast, <span>πΌ[π | π = π§] simply refers to the expected value in the (pre-intervention) population where individuals take whatever treatment they would normally take ( π ). This distinction will become important when we get to counterfactuals in <span>

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088933833996

Tags
#causality #statistics
Question
By β[...],β we mean whether any two nodes in a graph are associated or not associated. Another way of saying this is whether two nodes are (statistically) dependent or (statistically) independent.
flow of association

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
By βflow of association,β we mean whether any two nodes in a graph are associated or not associated. Another way of saying this is whether two nodes are (statistically) dependent or (statistically) independent

#### Original toplevel document (pdf)

cannot see any pdfs

#### Annotation 7088935669004

 #causality #has-images #statistics Consider the following general kind of path, where β Β· Β· Β· β denotes a directed path: π β Β· Β· Β· β π β Β· Β· Β· β π . Conditioning on π , or any descendant of π in a path like this, will induce collider bias. That is, the causal effect estimate will be biased by the non-causal association that we induce when we condition on π or any of its descendants (see Section 3.6).

#### Parent (intermediate) annotation

Open it
blocked by a collider. For example, this is the case with conditioning on π in Figure 4.13. This induces non-causal association between π and π , which biases the estimate of the causal effect. <span>Consider the following general kind of path, where β Β· Β· Β· β denotes a directed path: π β Β· Β· Β· β π β Β· Β· Β· β π . Conditioning on π , or any descendant of π in a path like this, will induce collider bias. That is, the causal effect estimate will be biased by the non-causal association that we induce when we condition on π or any of its descendants (see Section 3.6). <span>

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088937766156

Tags
#causality #statistics
Question
In observational data, it is unrealistic to assume that the treatment groups are [...]. In other words, there is no reason to expect that the groups are the same in all relevant variables other than the treatment.
exchangeable

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
In observational data, it is unrealistic to assume that the treatment groups are exchangeable. In other words, there is no reason to expect that the groups are the same in all relevant variables other than the treatment.

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088940387596

Tags
#causality #statistics
Question

Definition 3.3 (blocked path) A path between nodes π and π is blocked by a (potentially empty) conditioning set π if [...] of the following is true:

1. Along the path, there is a chain Β· Β· Β· β π β Β· Β· Β· or a fork Β· Β· Β· β π β Β· Β· Β·, where π is conditioned on (π β π).

2. There is a collider π on the path that is not conditioned on ( π β π ) and none of its descendants are conditioned on (de(π) * π)

either

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
Definition 3.3 (blocked path) A path between nodes π and π is blocked by a (potentially empty) conditioning set π if either of the following is true: 1. Along the path, there is a chain Β· Β· Β· β π β Β· Β· Β· or a fork Β· Β· Β· β π β Β· Β· Β·, where π is conditioned on (π β π). 2. There is a collider π on the path that

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088942222604

Tags
#causality #statistics
Question
It turns out that much of the work for causal graphical models was done in the field of [...] graphical models.
probabilistic

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
It turns out that much of the work for causal graphical models was done in the field of probabilistic graphical models.

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088944057612

Tags
#causality #statistics
Question

Assumption 3.2 (Minimality Assumption)

1. Given its parents in the DAG, a node π is independent of all its non-descendants (Assumption 3.1).

2. [...] nodes in the DAG are dependent.

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
Assumption 3.2 (Minimality Assumption) 1. Given its parents in the DAG, a node π is independent of all its non-descendants (Assumption 3.1). 2. Adjacent nodes in the DAG are dependent.

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088945892620

Tags
#causality #statistics
Question
Definition 3.2 (What is a cause?) A variable π is said to be a cause of a variable π if π can [...] in response to changes in π
change

status measured difficulty not learned 37% [default] 0

#### Parent (intermediate) annotation

Open it
Definition 3.2 (What is a cause?) A variable π is said to be a cause of a variable π if π can change in response to changes in π

#### Original toplevel document (pdf)

cannot see any pdfs

#### Flashcard 7088950086924

Question
La dΓ©finition de la philosophie tourne ainsi autour de 4 notions :
[default - edit me]

status measured difficulty not learned 37% [default] 0

#### pdf

cannot see any pdfs

#### Flashcard 7088951135500

Question
[default - edit me]
Le questionnement Le rationnel La critique La rΓ©alitΓ© dans son ensemble Une vie meilleure

status measured difficulty not learned 37% [default] 0

#### pdf

cannot see any pdfs

#### Annotation 7088958999820

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Monkeypox is a viral zoonotic infection that results in a rash similar to smallpox. However, the person-to-person spread and the mortality from a monkeypox infection are significantly lower than for smallpox. Clinically, these two viral infections are difficult to distinguish, raising concerns that monkeypox could be used for bioterrorism [1]

UpToDate
opics are updated as new evidence becomes available and our peer review process is complete. Literature review current through: Apr 2022. | This topic last updated: May 20, 2022. INTRODUCTION β <span>Monkeypox is a viral zoonotic infection that results in a rash similar to smallpox. However, the person-to-person spread and the mortality from a monkeypox infection are significantly lower than for smallpox. Clinically, these two viral infections are difficult to distinguish, raising concerns that monkeypox could be used for bioterrorism [1]. This topic will review the virology, epidemiology, clinical manifestations, diagnosis, and treatment of monkeypox. Topic reviews that discuss smallpox are presented separately. (See "V

#### Annotation 7088960048396

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Monkeypox, an orthopoxvirus, was first isolated in the late 1950s from a colony of sick monkeys. The virus is in the same genus as variola (causative agent of smallpox) and vaccinia viruses (the virus used in smallpox vaccine)

UpToDate
atment of monkeypox. Topic reviews that discuss smallpox are presented separately. (See "Variola virus (smallpox)" and "Identifying and managing casualties of biological terrorism".) VIROLOGY β <span>Monkeypox, an orthopoxvirus, was first isolated in the late 1950s from a colony of sick monkeys. The virus is in the same genus as variola (causative agent of smallpox) and vaccinia viruses (the virus used in smallpox vaccine). Electron microscopy of cells infected with monkeypox virus shows a brick-like virion, indistinguishable from the virions of variola or vaccinia viruses (picture 1). Two distinct strain

#### Annotation 7088961096972

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Two distinct strains of monkeypox exist in different geographic regions of Africa, as suggested by epidemiologic, animal, and molecular evidence [2]. In comparison to strains isolated from Central Africa, monkeypox from Western Africa is less virulent and lacks a number of genes present in the other viral strain [2,3]

UpToDate
s used in smallpox vaccine). Electron microscopy of cells infected with monkeypox virus shows a brick-like virion, indistinguishable from the virions of variola or vaccinia viruses (picture 1). <span>Two distinct strains of monkeypox exist in different geographic regions of Africa, as suggested by epidemiologic, animal, and molecular evidence [2]. In comparison to strains isolated from Central Africa, monkeypox from Western Africa is less virulent and lacks a number of genes present in the other viral strain [2,3]. EPIDEMIOLOGY History β It is believed that monkeypox virus has infected humans for thousands of years in sub-Saharan Africa [1]. Monkeypox was first identified as a cause of disease in

#### Annotation 7088962145548

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus History β It is believed that monkeypox virus has infected humans for thousands of years in sub-Saharan Africa [1]

UpToDate
ence [2]. In comparison to strains isolated from Central Africa, monkeypox from Western Africa is less virulent and lacks a number of genes present in the other viral strain [2,3]. EPIDEMIOLOGY <span>History β It is believed that monkeypox virus has infected humans for thousands of years in sub-Saharan Africa [1]. Monkeypox was first identified as a cause of disease in humans in the 1970s in the Democratic Republic of the Congo (formerly the Republic of Zaire) [1,4-7]. Following its recognition

#### Annotation 7088963194124

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Following its recognition as a human pathogen, 59 cases of human monkeypox were reported between 1970 and 1980, with a mortality rate of 17 percent. All of these cases occurred in the rain forests of Western and Central Africa among individuals exposed to small forest animals (eg, rodents, squirrels, and monkeys).

UpToDate
of years in sub-Saharan Africa [1]. Monkeypox was first identified as a cause of disease in humans in the 1970s in the Democratic Republic of the Congo (formerly the Republic of Zaire) [1,4-7]. <span>Following its recognition as a human pathogen, 59 cases of human monkeypox were reported between 1970 and 1980, with a mortality rate of 17 percent. All of these cases occurred in the rain forests of Western and Central Africa among individuals exposed to small forest animals (eg, rodents, squirrels, and monkeys). The first outbreak of monkeypox in the Western Hemisphere occurred in the United States in 2003 [8-10]. (See 'United States' below and 'Other countries' below.) Transmission βAnimal-to-

#### Annotation 7088964242700

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The first outbreak of monkeypox in the Western Hemisphere occurred in the United States in 2003 [8-10]. (See 'United States' below and 'Other countries' below.)

UpToDate
tality rate of 17 percent. All of these cases occurred in the rain forests of Western and Central Africa among individuals exposed to small forest animals (eg, rodents, squirrels, and monkeys). <span>The first outbreak of monkeypox in the Western Hemisphere occurred in the United States in 2003 [8-10]. (See 'United States' below and 'Other countries' below.) Transmission βAnimal-to-human transmission β The virus is typically acquired through contact with an infected animal's bodily fluids or through a bite. Monkeys and humans are incidental

#### Annotation 7088965291276

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Animal-to-human transmission β The virus is typically acquired through contact with an infected animal's bodily fluids or through a bite. Monkeys and humans are incidental hosts; the reservoir remains unknown but is likely to be rodents

UpToDate
els, and monkeys). The first outbreak of monkeypox in the Western Hemisphere occurred in the United States in 2003 [8-10]. (See 'United States' below and 'Other countries' below.) Transmission β<span>Animal-to-human transmission β The virus is typically acquired through contact with an infected animal's bodily fluids or through a bite. Monkeys and humans are incidental hosts; the reservoir remains unknown but is likely to be rodents. Infected rodents from Western Africa were accidentally imported into the United States; this led to the first human monkeypox infections in the Western Hemisphere. Based on findings du

#### Annotation 7088966339852

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Based on findings during a 2003 United States outbreak, the route of infection and extent of exposure (eg, bite wound versus touching an infected animal) can influence the severity of clinical manifestations of monkeypox infection. For example, one study categorized exposures to a prairie dog as noninvasive (eg, the person touched an infected animal, cleaned an infected animal's cage) or "complex" (eg, invasive bite or scratch from an ill prairie dog) [11]. Patients with complex exposures were more likely than patients with noninvasive exposures to develop signs of systemic illness. (See 'United States' below.)

UpToDate
but is likely to be rodents. Infected rodents from Western Africa were accidentally imported into the United States; this led to the first human monkeypox infections in the Western Hemisphere. <span>Based on findings during a 2003 United States outbreak, the route of infection and extent of exposure (eg, bite wound versus touching an infected animal) can influence the severity of clinical manifestations of monkeypox infection. For example, one study categorized exposures to a prairie dog as noninvasive (eg, the person touched an infected animal, cleaned an infected animal's cage) or "complex" (eg, invasive bite or scratch from an ill prairie dog) [11]. Patients with complex exposures were more likely than patients with noninvasive exposures to develop signs of systemic illness. (See 'United States' below.) βHuman-to-human transmission β Human-to-human transmission can occur through large respiratory droplets. Transmission can also occur through close contact with infectious skin lesions o

#### Annotation 7088967388428

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Human-to-human transmission β Human-to-human transmission can occur through large respiratory droplets. Transmission can also occur through close contact with infectious skin lesions or from contact with lesion material.

UpToDate
atch from an ill prairie dog) [11]. Patients with complex exposures were more likely than patients with noninvasive exposures to develop signs of systemic illness. (See 'United States' below.) β<span>Human-to-human transmission β Human-to-human transmission can occur through large respiratory droplets. Transmission can also occur through close contact with infectious skin lesions or from contact with lesion material. For droplet transmission, prolonged face-to-face contact may be required for transmission to occur (eg, within a six-foot radius for β₯3 hours in the absence of personal protection equip

#### Annotation 7088968437004

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus For droplet transmission, prolonged face-to-face contact may be required for transmission to occur (eg, within a six-foot radius for β₯3 hours in the absence of personal protection equipment [PPE]) [12].

UpToDate
β Human-to-human transmission can occur through large respiratory droplets. Transmission can also occur through close contact with infectious skin lesions or from contact with lesion material. <span>For droplet transmission, prolonged face-to-face contact may be required for transmission to occur (eg, within a six-foot radius for β₯3 hours in the absence of personal protection equipment [PPE]) [12]. In general, transmissibility from person to person is very low [13]. However, in a cluster of cases seen in May 2022, the risk of person-to-person transmission appears to be high [14].

#### Annotation 7088969485580

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Africa β From 1996 to 1998, an outbreak of febrile illness with associated pustular lesions occurred among about 100 persons with reports of secondary attack rates of 80 percent [4,7]

UpToDate
ve been reported in several other countries, mostly related to travel. In the United States, there was an outbreak due to importation of exotic animals from Africa. (See 'United States' below.) <span>Africa β From 1996 to 1998, an outbreak of febrile illness with associated pustular lesions occurred among about 100 persons with reports of secondary attack rates of 80 percent [4,7]. A concurrent chickenpox outbreak may have resulted in misclassification of cases and likely explained the high secondary attack rates. Nevertheless, this outbreak created concern that

#### Annotation 7088970534156

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Other factors associated with an increased risk of infection included living in forested areas, male sex, and age <15 years

UpToDate
man cases of monkeypox due to the lack of prior smallpox vaccination; persons with a history of smallpox immunization had a fivefold lower risk of monkeypox infection than unvaccinated persons. <span>Other factors associated with an increased risk of infection included living in forested areas, male sex, and age <15 years. Since 2017, there has been an increase in monkeypox cases in Nigeria; this occurred after almost 40 years with no reported cases [17]. Some of these cases have occurred among returning

#### Annotation 7088971582732

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Outbreak in 2003 β Between May 15 and June 2003, an outbreak of 71 cases of human monkeypox in six states was investigated by the Centers for Disease Control and Prevention (CDC); 35 cases were laboratory confirmed [8-10]. Prior to this cluster of cases, monkeypox had not been previously found in the Western hemisphere.

UpToDate
dy evaluating the 2017 outbreak, a small pool of related isolates was the likely source for the exported infections [18]. (See 'United States' below and 'Other countries' below.) United States β<span>Outbreak in 2003 β Between May 15 and June 2003, an outbreak of 71 cases of human monkeypox in six states was investigated by the Centers for Disease Control and Prevention (CDC); 35 cases were laboratory confirmed [8-10]. Prior to this cluster of cases, monkeypox had not been previously found in the Western hemisphere. The investigation demonstrated that the onset of a febrile illness, with subsequent appearance of a pustular rash, had developed in patients who had recently purchased pet prairie dogs.

#### Annotation 7088972631308

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus During this outbreak, monkeypox appeared to have a very low rate of person-to-person transmission. In one study of 57 health care workers who were exposed to patients with monkeypox, none reported signs and symptoms of disease [21]. Only one had laboratory evidence of recent orthopoxvirus infection, which was probably secondary to prior smallpox vaccination. By contrast, secondary attack rates for smallpox can be as high as 70 percent [5,22].

UpToDate
excluded. Of the cases reported in Wisconsin, the veterinary staff who were exposed to an outbreak-associated prairie dog were at particularly high risk, with an attack rate of 23 percent [20]. <span>During this outbreak, monkeypox appeared to have a very low rate of person-to-person transmission. In one study of 57 health care workers who were exposed to patients with monkeypox, none reported signs and symptoms of disease [21]. Only one had laboratory evidence of recent orthopoxvirus infection, which was probably secondary to prior smallpox vaccination. By contrast, secondary attack rates for smallpox can be as high as 70 percent [5,22]. Because of this outbreak, the transportation, sale, or release into the wild of prairie dogs and animals from Africa (including tree squirrels, rope squirrels, dormice, brush-tailed por

#### Annotation 7088973679884

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The United States outbreak described above allowed estimation of time from exposure to onset of symptoms. Approximately half of the patients reported a scratch, bite, or petting of an infected animal [31]. For 29 patients, the estimated incubation time from exposure to illness was 12 days. Persons with a history of an animal bite or scratch may have a shorter incubation period than those with tactile exposures (13 versus 9 days, respectively) [11]

UpToDate
a [29] and Australia [30]. These cases were not related to travel to endemic areas and appear to be related to the outbreak in Europe, described above. (See 'Europe' above.) INCUBATION PERIOD β <span>The United States outbreak described above allowed estimation of time from exposure to onset of symptoms. Approximately half of the patients reported a scratch, bite, or petting of an infected animal [31]. For 29 patients, the estimated incubation time from exposure to illness was 12 days. Persons with a history of an animal bite or scratch may have a shorter incubation period than those with tactile exposures (13 versus 9 days, respectively) [11]. CLINICAL MANIFESTATIONS β Based largely on seroepidemiological studies in Africa, the majority of monkeypox infections are asymptomatic. In symptomatic individuals, monkeypox causes a

#### Annotation 7088974728460

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Based largely on seroepidemiological studies in Africa, the majority of monkeypox infections are asymptomatic. In symptomatic individuals, monkeypox causes a systemic illness including fevers, chills, and myalgias, with a characteristic rash that is important to differentiate from that of smallpox. The clinical illness can also differ by viral strain.

UpToDate
days. Persons with a history of an animal bite or scratch may have a shorter incubation period than those with tactile exposures (13 versus 9 days, respectively) [11]. CLINICAL MANIFESTATIONS β <span>Based largely on seroepidemiological studies in Africa, the majority of monkeypox infections are asymptomatic. In symptomatic individuals, monkeypox causes a systemic illness including fevers, chills, and myalgias, with a characteristic rash that is important to differentiate from that of smallpox. The clinical illness can also differ by viral strain. (See 'Differential diagnosis' below.) Outbreaks in Africa β In Africa, the monkeypox rash starts on the trunk and then spreads peripherally to involve the palms and soles of the feet. L

#### Annotation 7088975777036

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Outbreaks in Africa β In Africa, the monkeypox rash starts on the trunk and then spreads peripherally to involve the palms and soles of the feet. Lesions can also involve the mucous membranes and usually range from 0.5 to 1 centimeter in size. The rash usually begins as macules and papules; the rash then progresses over a two- to four-week period to vesicles, pustules, followed by umbilication, scabbing, and desquamation. Some patients develop only a localized rash on their hands associated with direct contact with the infected animal.

UpToDate
s, and myalgias, with a characteristic rash that is important to differentiate from that of smallpox. The clinical illness can also differ by viral strain. (See 'Differential diagnosis' below.) <span>Outbreaks in Africa β In Africa, the monkeypox rash starts on the trunk and then spreads peripherally to involve the palms and soles of the feet. Lesions can also involve the mucous membranes and usually range from 0.5 to 1 centimeter in size. The rash usually begins as macules and papules; the rash then progresses over a two- to four-week period to vesicles, pustules, followed by umbilication, scabbing, and desquamation. Some patients develop only a localized rash on their hands associated with direct contact with the infected animal. United States outbreaks β Although comprehensive clinical information is limited on monkeypox in Africa, the 2003 United States outbreak allowed further characterization of the illness

#### Annotation 7088976825612

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus United States outbreaks β Although comprehensive clinical information is limited on monkeypox in Africa, the 2003 United States outbreak allowed further characterization of the illness in 34 of 37 subjects for whom medical records were available [31]. The predominant signs and symptoms were: β Rash (97 percent) β Fever (85 percent) β Chills (71 percent) β Lymphadenopathy (71 percent) β Headache (65 percent) β Myalgias (56 percent)

UpToDate
to vesicles, pustules, followed by umbilication, scabbing, and desquamation. Some patients develop only a localized rash on their hands associated with direct contact with the infected animal. <span>United States outbreaks β Although comprehensive clinical information is limited on monkeypox in Africa, the 2003 United States outbreak allowed further characterization of the illness in 34 of 37 subjects for whom medical records were available [31]. The predominant signs and symptoms were: βRash (97 percent) βFever (85 percent) βChills (71 percent) βLymphadenopathy (71 percent) βHeadache (65 percent) βMyalgias (56 percent) The onset of fever preceded the rash by approximately two days, but the median duration of fever was shorter than the rash (8 and 12 days, respectively). The following clinical pictures

#### Annotation 7088977874188

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The onset of fever preceded the rash by approximately two days, but the median duration of fever was shorter than the rash (8 and 12 days, respectively).

UpToDate
available [31]. The predominant signs and symptoms were: βRash (97 percent) βFever (85 percent) βChills (71 percent) βLymphadenopathy (71 percent) βHeadache (65 percent) βMyalgias (56 percent) <span>The onset of fever preceded the rash by approximately two days, but the median duration of fever was shorter than the rash (8 and 12 days, respectively). The following clinical pictures of the initial case identified in the United States were taken at the Marshfield Clinic in Wisconsin (picture 2A-D). The rash in this United States outbr

#### Annotation 7088978922764

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The following clinical pictures of the initial case identified in the United States were taken at the Marshfield Clinic in Wisconsin ( picture 2A-D). The rash in this United States outbreak was described as maculopapular in nature on initial presentation; the rash subsequently evolved into vesicles, then pustules, which eventually crusted within a two- to three-week period [31].

UpToDate
che (65 percent) βMyalgias (56 percent) The onset of fever preceded the rash by approximately two days, but the median duration of fever was shorter than the rash (8 and 12 days, respectively). <span>The following clinical pictures of the initial case identified in the United States were taken at the Marshfield Clinic in Wisconsin (picture 2A-D). The rash in this United States outbreak was described as maculopapular in nature on initial presentation; the rash subsequently evolved into vesicles, then pustules, which eventually crusted within a two- to three-week period [31]. Nine of the 34 patients were hospitalized for a variety of reasons, including nausea, vomiting, and dysphagia. The discharge diagnoses of two of the most seriously ill patients were enc

#### Annotation 7088979971340

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Nine of the 34 patients were hospitalized for a variety of reasons, including nausea, vomiting, and dysphagia. The discharge diagnoses of two of the most seriously ill patients were encephalopathy and a retropharyngeal abscess. All of the patients in this case series survived with supportive therapy; no antiviral therapy was administered.

UpToDate
k was described as maculopapular in nature on initial presentation; the rash subsequently evolved into vesicles, then pustules, which eventually crusted within a two- to three-week period [31]. <span>Nine of the 34 patients were hospitalized for a variety of reasons, including nausea, vomiting, and dysphagia. The discharge diagnoses of two of the most seriously ill patients were encephalopathy and a retropharyngeal abscess. All of the patients in this case series survived with supportive therapy; no antiviral therapy was administered. Multiple nonspecific laboratory findings were also noted including abnormal aminotransferases, leukocytosis, mild thrombocytopenia, and hypoalbuminemia. In the cluster of cases reported

#### Annotation 7088981019916

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Multiple nonspecific laboratory findings were also noted including abnormal aminotransferases, leukocytosis, mild thrombocytopenia, and hypoalbuminemia.

UpToDate
e most seriously ill patients were encephalopathy and a retropharyngeal abscess. All of the patients in this case series survived with supportive therapy; no antiviral therapy was administered. <span>Multiple nonspecific laboratory findings were also noted including abnormal aminotransferases, leukocytosis, mild thrombocytopenia, and hypoalbuminemia. In the cluster of cases reported in May 2022, it was noted that some patients may present with proctitis or with lesions located on the genital or perianal area alone [23,32]. DIAGNOSIS

#### Annotation 7088982068492

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus In the cluster of cases reported in May 2022, it was noted that some patients may present with proctitis or with lesions located on the genital or perianal area alone [23,32].

UpToDate
; no antiviral therapy was administered. Multiple nonspecific laboratory findings were also noted including abnormal aminotransferases, leukocytosis, mild thrombocytopenia, and hypoalbuminemia. <span>In the cluster of cases reported in May 2022, it was noted that some patients may present with proctitis or with lesions located on the genital or perianal area alone [23,32]. DIAGNOSIS β Although clinical features are helpful in making the diagnosis, laboratory confirmation of monkeypox virus is necessary to differentiate this disease from those caused by ot

#### Annotation 7088983117068

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Serum IgM and IgG antibodies were detected five and eight days after onset of rash, respectively [35].

UpToDate
the 2003 United States outbreak, the Centers for Disease Control and Prevention (CDC) developed an immunoglobulin M-capture and an IgG ELISA that demonstrated recent monkeypox virus infection. <span>Serum IgM and IgG antibodies were detected five and eight days after onset of rash, respectively [35]. Other experimental antibody and cellular based assays are under development, which may be useful for the prospective and retrospective diagnosis of monkeypox [22]. If the diagnosis of m

#### Annotation 7088984165644

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Several infections need to be considered in the differential diagnosis of monkeypox; these include varicella, herpes simplex virus, smallpox, and other poxviruses.

UpToDate
idered, local and state public health officials, along with the CDC, should be notified so that the samples are quickly processed. (See 'Differential diagnosis' below.) DIFFERENTIAL DIAGNOSIS β <span>Several infections need to be considered in the differential diagnosis of monkeypox; these include varicella, herpes simplex virus, smallpox, and other poxviruses. Given the worldwide eradication of smallpox, the most likely diagnostic consideration is varicella (chickenpox). Unlike varicella where vesicular lesions are characteristically in diffe

#### Annotation 7088985214220

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Unlike varicella where vesicular lesions are characteristically in different stages of development and healing when the patient is examined, monkeypox lesions are all generally at the same stage

UpToDate
; these include varicella, herpes simplex virus, smallpox, and other poxviruses. Given the worldwide eradication of smallpox, the most likely diagnostic consideration is varicella (chickenpox). <span>Unlike varicella where vesicular lesions are characteristically in different stages of development and healing when the patient is examined, monkeypox lesions are all generally at the same stage. (See "Clinical features of varicella-zoster virus infection: Chickenpox".) Because of concerns regarding bioterrorism, it is also important to consider the possibility of smallpox in t

#### Annotation 7088986262796

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Lymphadenopathy, which has been observed in the majority of unvaccinated patients, is a key distinguishing feature of monkeypox [10]. Lymphadenopathy can occur in the submandibular, cervical, or inguinal regions.

UpToDate
also important to consider the possibility of smallpox in the differential diagnosis of a patient who has not been in the rain forests of Africa or exposed to potentially infected animals [6]. <span>Lymphadenopathy, which has been observed in the majority of unvaccinated patients, is a key distinguishing feature of monkeypox [10]. Lymphadenopathy can occur in the submandibular, cervical, or inguinal regions. (See "Identifying and managing casualties of biological terrorism" and "Variola virus (smallpox)".) Also in the differential diagnosis is tanapox, another African poxvirus that causes a

#### Annotation 7088987311372

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Antivirals β Several antivirals may be useful for the treatment of monkeypox. These drugs were approved for treatment of smallpox based on animal models and dose studies in healthy humans but are expected to have the same activity against human monkeypox.

UpToDate
sea, vomiting, dysphagia) may require a short hospital stay for intravenous hydration. For the seriously ill patient, supportive care is necessary until the patient recovers from the infection. <span>Antivirals β Several antivirals may be useful for the treatment of monkeypox. These drugs were approved for treatment of smallpox based on animal models and dose studies in healthy humans but are expected to have the same activity against human monkeypox. (See "Variola virus (smallpox)", section on 'Antiviral therapy'.) In general, tecovirimat is the treatment of choice, though some experts may use dual therapy with tecovirimat and brinc

#### Annotation 7088988359948

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus In general, tecovirimat is the treatment of choice, though some experts may use dual therapy with tecovirimat and brincidofovir in patients with severe disease.

UpToDate
x based on animal models and dose studies in healthy humans but are expected to have the same activity against human monkeypox. (See "Variola virus (smallpox)", section on 'Antiviral therapy'.) <span>In general, tecovirimat is the treatment of choice, though some experts may use dual therapy with tecovirimat and brincidofovir in patients with severe disease. Treatment decisions should be made in consultation with local departments of health and/or the Centers for Disease Control and Prevention (CDC). In the United States, tecovirimat and br

#### Annotation 7088989408524

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Tecovirimat β In July 2018, tecovirimat was approved for use in the United States for treatment of smallpox [37]. This drug protects nonhuman primates from lethal monkeypox virus infections [37-39] and will likely be efficacious against this infection in humans as well. Tecovirimat is a potent inhibitor of an orthopoxvirus protein required for the formation of an infectious virus particle that is essential for dissemination within an infected host.

UpToDate
available through the United States government's Strategic National Stockpile. Additional information regarding management of monkeypox during an outbreak can be also found on the CDC website. <span>Tecovirimat β In July 2018, tecovirimat was approved for use in the United States for treatment of smallpox [37]. This drug protects nonhuman primates from lethal monkeypox virus infections [37-39] and will likely be efficacious against this infection in humans as well. Tecovirimat is a potent inhibitor of an orthopoxvirus protein required for the formation of an infectious virus particle that is essential for dissemination within an infected host. The recommended dose of tecovirimat depends upon the patient's weight, as described in manufacturer labeling and the Lexicomp drug information topic within UpToDate. The duration of tre

#### Annotation 7088990457100

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The recommended dose of tecovirimat depends upon the patient's weight, as described in manufacturer labeling and the Lexicomp drug information topic within UpToDate. The duration of treatment is 14 days. The most frequently reported side effects are headache, nausea, and abdominal pain.

UpToDate
ns as well. Tecovirimat is a potent inhibitor of an orthopoxvirus protein required for the formation of an infectious virus particle that is essential for dissemination within an infected host. <span>The recommended dose of tecovirimat depends upon the patient's weight, as described in manufacturer labeling and the Lexicomp drug information topic within UpToDate. The duration of treatment is 14 days. The most frequently reported side effects are headache, nausea, and abdominal pain. A more detailed discussion of this agent is found elsewhere. (See "Variola virus (smallpox)", section on 'Tecovirimat'.) Brincidofovir β In June 2021, brincidofovir was approved for use

#### Annotation 7088991505676

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus In Central Africa, the fatality rate is approximately 10 percent and deaths generally occur in the second week of illness [1,47]. In contrast, there were no deaths in the outbreak in the United States. These more favorable outcomes in the United States may be related to a healthier patient population, greater availability of supportive medical care, and a less virulent strain of monkeypox, which was imported from the West African nation of Ghana [31].

UpToDate
regarding its efficacy against monkeypox infection in humans and its use can be associated with significant adverse events, including nephrotoxicity. (See "Cidofovir: An overview".) MORTALITY β <span>In Central Africa, the fatality rate is approximately 10 percent and deaths generally occur in the second week of illness [1,47]. In contrast, there were no deaths in the outbreak in the United States. These more favorable outcomes in the United States may be related to a healthier patient population, greater availability of supportive medical care, and a less virulent strain of monkeypox, which was imported from the West African nation of Ghana [31]. PREVENTION β Data suggest that prior immunization with smallpox vaccine prevents infection and ameliorates symptoms. The role of postexposure prophylaxis with smallpox vaccine or vaccin

#### Annotation 7088992554252

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Data suggest that prior immunization with smallpox vaccine prevents infection and ameliorates symptoms. The role of postexposure prophylaxis with smallpox vaccine or vaccinia immunoglobulin is unclear, as discussed below.

UpToDate
althier patient population, greater availability of supportive medical care, and a less virulent strain of monkeypox, which was imported from the West African nation of Ghana [31]. PREVENTION β <span>Data suggest that prior immunization with smallpox vaccine prevents infection and ameliorates symptoms. The role of postexposure prophylaxis with smallpox vaccine or vaccinia immunoglobulin is unclear, as discussed below. Smallpox immunization β Prior smallpox vaccination with vaccinia virus has a significant protective effect against acquisition of monkeypox virus and may ameliorate the clinical manifes

#### Annotation 7088993602828

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus In the United States outbreak, further investigation using experimental techniques identified three additional monkeypox exposures in individuals who had previously received smallpox vaccination 13, 29, and 48 years prior to exposure to monkeypox [22]. These individuals were unaware that they had been infected because they did not have any recognizable disease symptoms. These findings suggested that the United States monkeypox outbreak was larger than previously realized. Furthermore, cross-protective antiviral immunity against West African monkeypox can potentially be maintained for decades after smallpox vaccination.

UpToDate
ed with unvaccinated persons (0.78 versus 4.05 per 10,000). In that study, vaccine efficacy was estimated to be approximately 81 percent in those with a distant history of smallpox vaccination. <span>In the United States outbreak, further investigation using experimental techniques identified three additional monkeypox exposures in individuals who had previously received smallpox vaccination 13, 29, and 48 years prior to exposure to monkeypox [22]. These individuals were unaware that they had been infected because they did not have any recognizable disease symptoms. These findings suggested that the United States monkeypox outbreak was larger than previously realized. Furthermore, cross-protective antiviral immunity against West African monkeypox can potentially be maintained for decades after smallpox vaccination. Postexposure prophylaxis Postexposure vaccination β In addition to monitoring and isolating close contacts, postexposure vaccination with MVA vaccine may be considered for certain patie

#### Annotation 7088994651404

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus . Public Health England developed risk assessment and public health recommendations for persons potentially exposed that are summarized in the table (table 1) [26].

UpToDate
ypox (eg, direct contact with patient or materials from patientβs room without personal protection equipment (PPE) [26]). This decision must be made in conjunction with public health authorities<span>. Public Health England developed risk assessment and public health recommendations for persons potentially exposed that are summarized in the table (table 1) [26]. Since prior vaccination with vaccinia virus protects against monkeypox infection, the Centers for Disease Control and Prevention (CDC) recommended vaccination with vaccinia virus for th

#### Annotation 7088995699980

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus The CDC also recommended pre-exposure vaccination for those involved in the investigation of the outbreak and for health care workers caring for patients with monkeypox [8,10]. Twenty-eight adults and two children received the smallpox vaccine for this purpose and no cases of monkeypox were identified among these recipients [10].

UpToDate
revention (CDC) recommended vaccination with vaccinia virus for the limited number of individuals exposed to monkeypox in the 2003 United States outbreak, including children and pregnant women. <span>The CDC also recommended pre-exposure vaccination for those involved in the investigation of the outbreak and for health care workers caring for patients with monkeypox [8,10]. Twenty-eight adults and two children received the smallpox vaccine for this purpose and no cases of monkeypox were identified among these recipients [10]. Furthermore, no cases of monkeypox were identified during pregnancy during the 2003 outbreak; it is not known if the infection carries a different prognosis in pregnant women [49]. Base

#### Annotation 7088996748556

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Based on historical data on postexposure vaccination for smallpox with vaccinia vaccine, the optimal time for monkeypox postexposure vaccination is within four days; however, vaccination can be considered for up to 14 days of a close contact exposure, according to the CDC [50].

UpToDate
pients [10]. Furthermore, no cases of monkeypox were identified during pregnancy during the 2003 outbreak; it is not known if the infection carries a different prognosis in pregnant women [49]. <span>Based on historical data on postexposure vaccination for smallpox with vaccinia vaccine, the optimal time for monkeypox postexposure vaccination is within four days; however, vaccination can be considered for up to 14 days of a close contact exposure, according to the CDC [50]. Close contact is defined as direct exposure within six feet of a probable or confirmed monkeypox case in an animal with respiratory symptoms such as nasal discharge, cough, or conjuncti

#### Annotation 7088997797132

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Close contact is defined as direct exposure within six feet of a probable or confirmed monkeypox case in an animal with respiratory symptoms such as nasal discharge, cough, or conjunctivitis in a setting where the animal has been manipulated (eg, an exam room) [ 50].

UpToDate
ne, the optimal time for monkeypox postexposure vaccination is within four days; however, vaccination can be considered for up to 14 days of a close contact exposure, according to the CDC [50]. <span>Close contact is defined as direct exposure within six feet of a probable or confirmed monkeypox case in an animal with respiratory symptoms such as nasal discharge, cough, or conjunctivitis in a setting where the animal has been manipulated (eg, an exam room) [50]. (See "Vaccinia virus as the smallpox vaccine" and "Immunizations during pregnancy", section on 'Smallpox'.) Vaccinia immune globulin β The use of vaccinia immune globulin may be conside

#### Annotation 7088998845708

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus Vaccinia immune globulin β The use of vaccinia immune globulin may be considered in immunosuppressed patients with an exposure history, since immunization with vaccinia virus vaccine is contraindicated [1].

UpToDate
nctivitis in a setting where the animal has been manipulated (eg, an exam room) [50]. (See "Vaccinia virus as the smallpox vaccine" and "Immunizations during pregnancy", section on 'Smallpox'.) <span>Vaccinia immune globulin β The use of vaccinia immune globulin may be considered in immunosuppressed patients with an exposure history, since immunization with vaccinia virus vaccine is contraindicated [1]. Infection control precautions β Use of both contact and airborne precautions are recommended for any generalized vesicular rash of unknown etiology in which monkeypox and smallpox are i

#### Annotation 7088999894284

 #Maladies-infectieuses-et-tropicales #Monkeypox #Orthopoxvirus #Variole-du-singe #Virus During the first week of the rash, persons with suspected monkeypox should be considered infectious and be isolated until all scabs separate and results of throat swab polymerase chain reaction (PCR) are negative [1].